期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 5, 页码 341-343出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.157
关键词
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Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl (LDT) chemistry. This approach was applied not only for chemically labeling proteins in living cells, tissues and mice but also for constructing a biosensor directly inside cells without genetic engineering. These data establish LDT chemistry as a new tool for the study and manipulation of biological systems.
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