期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 7, 页码 479-483出版社
NATURE RESEARCH
DOI: 10.1038/nchembio.180
关键词
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资金
- Max Kade Foundation
- US National Institutes of Health [GM59957]
In lead discovery, libraries of 106 molecules are screened for biological activity. Given the over 1060 drug-like molecules thought possible, such screens might never succeed. The fact that they do, even occasionally, implies a biased selection of library molecules. We have developed a method to quantify the bias in screening libraries toward biogenic molecules. With this approach, we consider what is missing from screening libraries and how they can be optimized.
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