期刊
NATURE CHEMICAL BIOLOGY
卷 6, 期 1, 页码 22-24出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.277
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资金
- Elsa U. Pardee Foundation
- American Cancer Society
- US National Institutes of Health [NIH-5U19-AI-067798-04, NIH-R01-CA129190]
- NATIONAL CANCER INSTITUTE [R01CA129190] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI067798] Funding Source: NIH RePORTER
In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.
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