期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 3, 页码 131-134出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio0309-131
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资金
- Medical Research Council [G9811527] Funding Source: researchfish
- MRC [G9811527] Funding Source: UKRI
- Intramural NIH HHS [Z99 DA999999] Funding Source: Medline
- Medical Research Council [G9811527] Funding Source: Medline
- NIDA NIH HHS [R01 DA007223, K05 DA022413] Funding Source: Medline
- NIMH NIH HHS [R01 MH054137] Funding Source: Medline
Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.
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