期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 7, 页码 448-449出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.f.11
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资金
- NIDDK NIH HHS [R01 DK037871] Funding Source: Medline
- NIGMS NIH HHS [R01 GM030324, R01 GM068820] Funding Source: Medline
Small-molecule inhibitors can induce phosphorylation priming of AGC kinases. Priming by ATP binding pocket conformation, rather than intrinsic kinase activity, has significant implications for drug discovery and therapeutic efficacy.
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