期刊
NATURE CHEMICAL BIOLOGY
卷 6, 期 1, 页码 19-21出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.265
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资金
- Deutsche Forschungsgemeinschaft [WI 3411/1-1]
The availability of whole genome sequences boosts the identification of biochemical pathways conserved across species using tools of comparative genomics. A cross-organism protein association analysis allowed us to identify two enzymes, ureidoglycine aminohydrolase and ureidoglycolate amidohydrolase, that catalyze the final reactions of purine degradation in the model plant Arabidopsis thaliana. A similar pathway was found in Escherichia coli, while an alternative metabolic route via ureidoglycine transaminase can be predicted for other organisms.
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