期刊
NATURE CHEMICAL BIOLOGY
卷 4, 期 6, 页码 344-346出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.88
关键词
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资金
- NIGMS NIH HHS [R01 GM068680, R01 GM068680-03, GM068680] Funding Source: Medline
By methylation of peptide arrays, we determined the specificity profile of the protein methyltransferase G9a. We show that it mostly recognizes an Arg-Lys sequence and that its activity is inhibited by methylation of the arginine residue. Using the specificity profile, we identified new non-histone protein targets of G9a, including CDYL1, WIZ, ACINUS and G9a (automethylation), as well as peptides derived from CSB. We demonstrate potential downstream signaling pathways for methylation of non-histone proteins.
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