期刊
NATURE CHEMICAL BIOLOGY
卷 4, 期 8, 页码 458-465出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.102
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资金
- NIGMS NIH HHS [GM-53757] Funding Source: Medline
The thermodynamic principle of cooperativity is used to drive the formation of specific macromolecular complexes during the assembly of a macromolecular machine. Understanding cooperativity provides insight into the mechanisms that govern assembly and disassembly of multicomponent complexes. Our understanding of assembly mechanisms is lagging considerably behind our understanding of the structure and function of these complexes. A significant challenge remains in tackling the thermodynamics and kinetics of the intermolecular interactions required for all cellular functions.
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