期刊
NATURE CHEMICAL BIOLOGY
卷 4, 期 6, 页码 341-343出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.84
关键词
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资金
- NIGMS NIH HHS [GM071425, R01 GM071425, R01 GM071425-01A1, R01 GM071425-03, R01 GM071425-02] Funding Source: Medline
More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.
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