4.8 Editorial Material

Metabolic control of ferroptosis in cancer

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NATURE CELL BIOLOGY
卷 20, 期 10, 页码 1104-1105

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NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0209-x

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  1. Medical Research Council [MC_UU_00015/3] Funding Source: Medline
  2. MRC [MC_UU_00015/3] Funding Source: UKRI

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Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

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