期刊
NATURE CELL BIOLOGY
卷 16, 期 6, 页码 488-494出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2976
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- Ligue Nationale contre le Cancer
- Association pour la Recherche contre le Cancer (ARC)
- Institut National du Cancer [PLBI009]
- Lyon integrated Research Institute in Cancer (LYRIC)
- LabEx DEVweCAN of Lyon University, within the program 'Investissements d'Avenir' [ANR-10-LABX-0061, ANR-11-IDEX-0007]
- DFG [BR1399/6-1, SFB850, B2, SFB992, C06]
- Deutsche Krebshilfe [109430]
- Agence Nationale de la Recherche (ANR) [ANR-10-LABX-0061] Funding Source: Agence Nationale de la Recherche (ANR)
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
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