期刊
NATURE CELL BIOLOGY
卷 14, 期 2, 页码 186-191出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2404
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资金
- Swiss National Science Foundation
- Muscular Dystrophy Association
- Canadian Institutes of Health Research
- National Institutes of Health
- Howard Hughes Medical Institute
- Canada Research Chair
Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal muscle. In differentiated myofibres, we observed that Wnt7a binding to Fzd7 directly activates the Akt/mTOR growth pathway, thereby inducing myofibre hypertrophy. Notably, the Fzd7 receptor complex was associated with G alpha(s) and PI(3)K and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. Wnt7a-Fzd7 activation of this pathway was completely independent of IGF-receptor activation. Together, these experiments demonstrate that Wnt7a-Fzd7 activates distinct pathways at different developmental stages during myogenic lineage progression, and identify a non-canonical anabolic signalling pathway for Wnt7a and its receptor Fzd7 in skeletal muscle.
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