期刊
NATURE CELL BIOLOGY
卷 13, 期 9, 页码 1016-1023出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2329
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资金
- NIH [R01 DK080425, 1P01CA120964]
- American Cancer Society
- American Diabetes Association
- Howard Hughes Medical Institute
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.
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