期刊
NATURE CELL BIOLOGY
卷 13, 期 7, 页码 771-U401出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2269
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资金
- Centre National de la Recherche Scientifique
- Institut Curie
- ANR [ANR-06-PCVI-0010]
- HFSP
- Boehringer Ingelheim Fonds
- Association pour la Recherche sur le Cancer
- Agence Nationale de la Recherche (ANR) [ANR-06-PCVI-0010] Funding Source: Agence Nationale de la Recherche (ANR)
The response of cells to forces is essential for tissue morphogenesis and homeostasis. This response has been extensively investigated in interphase cells, but it remains unclear how forces affect dividing cells. We used a combination of micro-manipulation tools on human dividing cells to address the role of physical parameters of the micro-environment in controlling the cell division axis, a key element of tissue morphogenesis. We found that forces applied on the cell body direct spindle orientation during mitosis. We further show that external constraints induce a polarization of dynamic sub cortical actin structures that correlate with spindle movements. We propose that cells divide according to cues provided by their mechanical micro-environment, aligning daughter cells with the external force field.
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