期刊
NATURE CELL BIOLOGY
卷 13, 期 5, 页码 589-U207出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2220
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资金
- 'Bolsa de Doutoramento' of the 'Fundacao para a Ciencia e Tecnologia', Portugal
- Telethon Italy [S02016]
- AIRC Italy
- Swiss National Foundation SNF [31-118171]
A plethora of cellular processes, including apoptosis, depend on regulated changes in mitochondrial shape and ultrastructure. The role of mitochondria and of their morphology during autophagy, a bulk degradation and recycling process of eukaryotic cells' constituents, is not well understood. Here we show that mitochondrial morphology determines the cellular response to macroautophagy. When autophagy is triggered, mitochondria elongate in vitro and in vivo. During starvation, cellular cyclic AMP levels increase and protein kinase A (PKA) is activated. PKA in turn phosphorylates the pro-fission dynamin-related protein 1 (DRP1), which is therefore retained in the cytoplasm, leading to unopposed mitochondria! fusion. Elongated mitochondria are spared from autophagic degradation, possess more cristae, increased levels of dimerization and activity of ATP synthase, and maintain ATP production. Conversely, when elongation is genetically or pharmacologically blocked, mitochondria consume ATP, precipitating starvation-induced death. Thus, regulated changes in mitochondrial morphology determine the fate of the cell during autophagy.
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