期刊
NATURE CELL BIOLOGY
卷 13, 期 2, 页码 112-114出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0211-112
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- Medical Research Council [G0800784] Funding Source: Medline
- Wellcome Trust [064421] Funding Source: Medline
- MRC [G0800784] Funding Source: UKRI
- Medical Research Council [G0800784B, G0800784] Funding Source: researchfish
In the mouse embryo, the first differences between cells that result in distinct lineages have long been thought to arise only as a consequence of differential cell positioning at relatively late preimplantation stages. Differences in Oct4 transcription factor kinetics between cells at the 4-8-cell stage are now shown to be predictive of future lineages, providing further evidence for much earlier initiation of cell fate decisions.
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