期刊
NATURE CELL BIOLOGY
卷 13, 期 4, 页码 402-U142出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2218
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类别
资金
- Tri-Institutional Starr Foundation
- NYSTEM
- NIH [EY11307, EY016805]
- RPB
- Tohoku University
- New Energy and Industrial Technology Development Organization
- Ministry of Education, Science, Sports, and Culture of Japan
- Grants-in-Aid for Scientific Research [23770136] Funding Source: KAKEN
Primary cilia are displayed during the G(0)/G(1) phase of many cell types. Cilia are resorbed as cells prepare to re-enter the cell cycle, but the causal and molecular link between these two cellular events remains unclear. We show that Tctex-1 phosphorylated at Thr 94 is recruited to ciliary transition zones before S-phase entry and has a pivotal role in both ciliary disassembly and cell cycle progression. However, the role of Tctex-1 in S-phase entry is dispensable in non-ciliated cells. Exogenously adding a phosphomimic Tctex-1(T94E) mutant accelerates cilium disassembly and S-phase entry. These results support a model in which the cilia act as a brake to prevent cell cycle progression. Mechanistic studies show the involvement of actin dynamics in Tctex-1-regulated cilium resorption. Tctex-1 phosphorylated at Thr 94 is also selectively enriched at the ciliary transition zones of cortical neural progenitors, and has a key role in controlling G(1) length, cell cycle entry and fate determination of these cells during corticogenesis.
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