期刊
NATURE CELL BIOLOGY
卷 12, 期 9, 页码 842-846出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0910-842
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资金
- Ligue Nationale contre le Cancer (equipe labellisee)
- Fondation pour la Recherche Medicate
- European Union
- Canceropole Ile-de-France
- Institut National du Cancer
- Agence Nationale pour la Recherche
- Austrian Science Fund [S-9304-B05]
- European Commission (APOSYS)
- European Research Council (ERC)
- European Commission
- European Molecular Biology Organization (EMBO)
Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.
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