期刊
NATURE BIOTECHNOLOGY
卷 36, 期 11, 页码 1056-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.4239
关键词
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资金
- NIH [K08 CA188615, R01 CA227388]
- Prostate Cancer Foundation-V Foundation Challenge Award
- BroadNext10
We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development.
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