4.8 Article

Intron retention is a source o neoepitopes in cancer

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NATURE BIOTECHNOLOGY
卷 36, 期 11, 页码 1056-+

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NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.4239

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资金

  1. NIH [K08 CA188615, R01 CA227388]
  2. Prostate Cancer Foundation-V Foundation Challenge Award
  3. BroadNext10

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We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development.

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