相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
Hiroko Koike-Yusa et al.
NATURE BIOTECHNOLOGY (2014)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem et al.
SCIENCE (2014)
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
Tim Wang et al.
SCIENCE (2014)
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Haoyi Wang et al.
CELL (2013)
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi et al.
CELL (2013)
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen et al.
CELL (2013)
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
F. Ann Ran et al.
CELL (2013)
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
Luke A. Gilbert et al.
CELL (2013)
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
Bin Shen et al.
CELL RESEARCH (2013)
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
Albert W. Cheng et al.
CELL RESEARCH (2013)
The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori
Yueqiang Wang et al.
CELL RESEARCH (2013)
Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos
Nannan Chang et al.
CELL RESEARCH (2013)
Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs
Qiurong Ding et al.
CELL STEM CELL (2013)
Simple and Efficient CRISPR/Cas9-Mediated Targeted Mutagenesis in Xenopus tropicalis
Takuya Nakayama et al.
GENESIS (2013)
Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans
Iskra Katic et al.
GENETICS (2013)
Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR-Cas9 System
Yonatan B. Tzur et al.
GENETICS (2013)
Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease
Scott J. Gratz et al.
GENETICS (2013)
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
Te-Wen Lo et al.
GENETICS (2013)
Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas
Hui Chiu et al.
GENETICS (2013)
CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans
Selma Waaijers et al.
GENETICS (2013)
Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9-sgRNA Ribonucleoproteins
Seung Woo Cho et al.
GENETICS (2013)
Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila
Zhongsheng Yu et al.
GENETICS (2013)
RNA-Guided Genome Editing in Plants Using a CRISPRCas System
Kabin Xie et al.
MOLECULAR PLANT (2013)
Optical control of mammalian endogenous transcription and epigenetic states
Silvana Konermann et al.
NATURE (2013)
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
Morgan L. Maeder et al.
NATURE BIOTECHNOLOGY (2013)
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
Prashant Mali et al.
NATURE BIOTECHNOLOGY (2013)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
Locus-specific editing of histone modifications at endogenous enhancers
Eric M. Mendenhall et al.
NATURE BIOTECHNOLOGY (2013)
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Seung Woo Cho et al.
NATURE BIOTECHNOLOGY (2013)
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
Jian-Feng Li et al.
NATURE BIOTECHNOLOGY (2013)
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
Wei Li et al.
NATURE BIOTECHNOLOGY (2013)
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease
Vladimir Nekrasov et al.
NATURE BIOTECHNOLOGY (2013)
Efficient genome editing in zebrafish using a CRISPR-Cas system
Woong Y. Hwang et al.
NATURE BIOTECHNOLOGY (2013)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Vikram Pattanayak et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
Dali Li et al.
NATURE BIOTECHNOLOGY (2013)
Targeted genome modification of crop plants using a CRISPR-Cas system
Qiwei Shan et al.
NATURE BIOTECHNOLOGY (2013)
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Wenyan Jiang et al.
NATURE BIOTECHNOLOGY (2013)
RNA-guided gene activation by CRISPR-Cas9-based transcription factors
Pablo Perez-Pinera et al.
NATURE METHODS (2013)
Robust, synergistic regulation of human gene expression using TALE activators
Morgan L. Maeder et al.
NATURE METHODS (2013)
CRISPR RNA-guided activation of endogenous human genes
Morgan L. Maeder et al.
NATURE METHODS (2013)
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Kevin M. Esvelt et al.
NATURE METHODS (2013)
Synergistic and tunable human gene activation by combinations of synthetic transcription factors
Pablo Perez-Pinera et al.
NATURE METHODS (2013)
Heritable genome editing in C. elegans via a CRISPR-Cas9 system
Ari E. Friedland et al.
NATURE METHODS (2013)
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran et al.
NATURE PROTOCOLS (2013)
INNOVATION TALENs: a widely applicable technology for targeted genome editing
J. Keith Joung et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells
Maarten Holkers et al.
NUCLEIC ACIDS RESEARCH (2013)
Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
An Xiao et al.
NUCLEIC ACIDS RESEARCH (2013)
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
Thomas J. Cradick et al.
NUCLEIC ACIDS RESEARCH (2013)
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
David Bikard et al.
NUCLEIC ACIDS RESEARCH (2013)
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
Wenzhi Jiang et al.
NUCLEIC ACIDS RESEARCH (2013)
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
James E. DiCarlo et al.
NUCLEIC ACIDS RESEARCH (2013)
Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System
Woong Y. Hwang et al.
PLOS ONE (2013)
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
Li-En Jao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
Zhonggang Hou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
Krzysztof Chylinski et al.
RNA BIOLOGY (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
Hirotaka Ebina et al.
SCIENTIFIC REPORTS (2013)
Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System
Andrew R. Bassett et al.
CELL REPORTS (2013)
RNA-Guided Genome Editing for Target Gene Mutations in Wheat
Santosh Kumar Upadhyay et al.
G3-GENES GENOMES GENETICS (2013)
Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system
Takuro Horii et al.
PEERJ (2013)
Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme
Jianbin Wang et al.
GENOME RESEARCH (2012)
Precision genome engineering with programmable DNA-nicking enzymes
Eunji Kim et al.
GENOME RESEARCH (2012)
RNA-guided genetic silencing systems in bacteria and archaea
Blake Wiedenheft et al.
NATURE (2012)
FLASH assembly of TALENs for high-throughput genome editing
Deepak Reyon et al.
NATURE BIOTECHNOLOGY (2012)
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
Thomas Gaj et al.
NATURE METHODS (2012)
An optimized two-finger archive for ZFN-mediated gene targeting
Ankit Gupta et al.
NATURE METHODS (2012)
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
Cherie L. Ramirez et al.
NUCLEIC ACIDS RESEARCH (2012)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Memory of viral infections by CRISPR-Cas adaptive immune systems: Acquisition of new information
Peter C. Fineran et al.
VIROLOGY (2012)
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
George Silva et al.
CURRENT GENE THERAPY (2011)
Genome Engineering With Zinc-Finger Nucleases
Dana Carroll
GENETICS (2011)
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
Elitza Deltcheva et al.
NATURE (2011)
A TALE nuclease architecture for efficient genome editing
Jeffrey C. Miller et al.
NATURE BIOTECHNOLOGY (2011)
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
Feng Zhang et al.
NATURE BIOTECHNOLOGY (2011)
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)
Jeffry D. Sander et al.
NATURE METHODS (2011)
Live-cell dSTORM with SNAP-tag fusion proteins
Teresa Klein et al.
NATURE METHODS (2011)
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
Rimantas Sapranauskas et al.
NUCLEIC ACIDS RESEARCH (2011)
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
Blake Wiedenheft et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence
Ekaterina Semenova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Xanthomonas AvrBs3 Family-Type III Effectors: Discovery and Function
Jens Boch et al.
ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 48 (2010)
Modular system for the construction of zinc-finger libraries and proteins
Beatriz Gonzalez et al.
NATURE PROTOCOLS (2010)
Genome editing with engineered zinc finger nucleases
Fyodor D. Urnov et al.
NATURE REVIEWS GENETICS (2010)
CRISPR/Cas, the Immune System of Bacteria and Archaea
Philippe Horvath et al.
SCIENCE (2010)
A Simple Cipher Governs DNA Recognition by TAL Effectors
Matthew J. Moscou et al.
SCIENCE (2009)
Rapid Open-Source engineering of customized zinc-finger nucleases for highly efficient gene modification
Morgan L. Maeder et al.
MOLECULAR CELL (2008)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
Julianne Smith et al.
NUCLEIC ACIDS RESEARCH (2006)
Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange
Felipe Cortes-Ledesma et al.
EMBO REPORTS (2006)
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action
Kira S. Makarova et al.
BIOLOGY DIRECT (2006)
Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly
David A. Wright et al.
NATURE PROTOCOLS (2006)
Design, construction and in vitro testing of zinc finger nucleases
Dana Carroll et al.
NATURE PROTOCOLS (2006)
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
DH Haft et al.
PLOS COMPUTATIONAL BIOLOGY (2005)
Single-strand interruptions in replicating chromosomes cause double-strand breaks
A Kuzminov
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)