期刊
NATURE BIOTECHNOLOGY
卷 31, 期 6, 页码 530-532出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.2595
关键词
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资金
- Croucher scholarship
- Howard Hughes Medical Institute
- US National Institutes of Health [R37-HD045022, R01-CA084198, R01-HG000257]
The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes-Sry and Uty. TALEN-mediated gene editing is a useful tool for dissecting the biology of the Y chromosome.
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