期刊
NATURE BIOTECHNOLOGY
卷 30, 期 3, 页码 261-264出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.2141
关键词
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资金
- European Molecular Biology Organization
- Juvenile Diabetes Research Foundation
Insulin-expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells in vitro. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
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