期刊
NATURE BIOTECHNOLOGY
卷 28, 期 4, 页码 365-U94出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.1613
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资金
- Two Blades Foundation
- Gatsby Charitable Foundation
- Research Council for Earth and Life Sciences of the Netherlands Organization for Scientific Research
- European Research Area Networks Plant Genomics
- BBSRC [BB/G024936/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G024936/1] Funding Source: researchfish
Plant diseases cause massive losses in agriculture. Increasing the natural defenses of plants may reduce the impact of phytopathogens on agricultural productivity. Pattern-recognition receptors (PRRs) detect microbes by recognizing conserved pathogen-associated molecular patterns (PAMPs)(1-3). Although the overall importance of PAMP-triggered immunity for plant defense is established(2,3), it has not been used to confer disease resistance in crops. We report that activity of a PRR is retained after its transfer between two plant families. Expression of EFR (ref. 4), a PRR from the cruciferous plant Arabidopsis thaliana, confers responsiveness to bacterial elongation factor Tu in the solanaceous plants Nicotiana benthamiana and tomato (Solanum lycopersicum), making them more resistant to a range of phytopathogenic bacteria from different genera. Our results in controlled laboratory conditions suggest that heterologous expression of PAMP recognition systems could be used to engineer broad-spectrum disease resistance to important bacterial pathogens, potentially enabling more durable and sustainable resistance in the field.
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