期刊
NATURE BIOTECHNOLOGY
卷 27, 期 5, 页码 459-461出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.1535
关键词
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资金
- NINDS NIH HHS [K08 NS048118-04, F32 NS058042, K08 NS048118-02, F32 NS058042-02, K08 NS048118-01A1, R01 NS057221-01A1, K08 NS048118, K08 NS48118, R01 NS057221-02, R01 NS057221, K08 NS048118-03, F32NS058042] Funding Source: Medline
This report demonstrates that introduction of microRNAs (miRNAs) specific to embryonic stem cells enhances the production of mouse induced pluripotent stem (iPS) cells. The miRNAs miR-291-3p, miR-294 and miR-295 increase the efficiency of reprogramming by Oct4, Sox2 and Klf4, but not by these factors plus cMyc. cMyc binds the promoter of the miRNAs, suggesting that they are downstream effectors of cMyc during reprogramming. However, unlike cMyc, the miRNAs induce a homogeneous population of iPS cell colonies.
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