期刊
NATURE BIOTECHNOLOGY
卷 27, 期 12, 页码 1173-1175出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.1589
关键词
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资金
- Burroughs Wellcome Fund
We present a method that harnesses massively parallel DNA synthesis and sequencing for the high-throughput functional analysis of regulatory sequences at single-nucleotide resolution. As a proof of concept, we quantitatively assayed the effects of all possible single-nucleotide mutations for three bacteriophage promoters and three mammalian core promoters in a single experiment per promoter. The method may also serve as a rapid screening tool for regulatory element engineering in synthetic biology.
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