期刊
NATURE BIOTECHNOLOGY
卷 26, 期 7, 页码 795-797出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1418
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylase ( HDAC) inhibitors improve reprogramming efficiency. In particular, valproic acid (VPA), an HDAC inhibitor, improves reprogramming efficiency by more than 100-fold, using Oct4-GFP as a reporter. VPA also enables efficient induction of pluripotent stem cells without introduction of the oncogene c-Myc.
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