期刊
NATURE
卷 554, 期 7690, 页码 56-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature25473
关键词
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资金
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [649024]
- Max Planck Society
- Francis Crick Institute [FC001162]
- Cancer Research UK
- UK Medical Research Council
- Wellcome Trust
- The Francis Crick Institute [10162] Funding Source: researchfish
The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.
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