期刊
NATURE
卷 509, 期 7501, 页码 439-446出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature13193
关键词
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资金
- Paul Glenn Foundation
- National Institutes of Health [R01CA96985, R01CA166347, AG41122-01P2]
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
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