期刊
NATURE
卷 514, 期 7521, 页码 181-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nature13793
关键词
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资金
- Weizmann Institute management
- Nancy and Stephen Grand Israel National Center for Personalized Medicine (INCPM)
- Boehringer Ingelheim Fonds PhD Fellowship
- Morris Kahn Fellowships for Systems Biology
- National Institute of Health (NIH)
- European Research Council (ERC)
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- estate of J. Gitlitz
- estate of L. Hershkovich
- Rising Tide foundation
- Minerva Stiftung foundation
- European Research Council
Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.
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