期刊
NATURE
卷 515, 期 7526, 页码 222-U151出版社
NATURE PORTFOLIO
DOI: 10.1038/nature13964
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资金
- Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative
- National Institutes of Health grants: K99 award from NIDCD [DC012069]
- NIAID Vectorbase DBP [HHSN272200900039C]
- CTSA award from NCATS [5UL1TR000043]
- Swedish Research Council and SLU: Insect Chemical Ecology and Evolution (IC-E3)
Female mosquitoes are major vectors of human disease and the most dangerous are those that preferentially bite humans. A 'domestic' form of the mosquito Aedes aegypti has evolved to specialize in biting humans and is the main worldwide vector of dengue, yellow fever, and chikungunya viruses. The domestic form coexists with an ancestral, 'forest' form that prefers to bite non-human animals and is found along the coast of Kenya. We collected the two forms, established laboratory colonies, and document striking divergence in preference for human versus non-human animal odour. We further show that the evolution of preference for human odour in domestic mosquitoes is tightly linked to increases in the expression and ligand-sensitivity of the odorant receptor AaegOr4, which we found recognizes a compound present at high levels inhuman odour. Our results provide a rare example of a gene contributing to behavioural evolution and provide insight into how disease-vectoring mosquitoes came to specialize on humans.
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