期刊
NATURE
卷 510, 期 7503, 页码 76-83出版社
NATURE PORTFOLIO
DOI: 10.1038/nature13477
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资金
- FP7 BetaBAT
- BBSRC
- BHF
- MRC
- Wellcome Trust
- Cambridge Overseas Trust
- Biotechnology and Biological Sciences Research Council [BB/J009865/1, BB/H002731/1] Funding Source: researchfish
- British Heart Foundation [PG/12/53/29714] Funding Source: researchfish
- Medical Research Council [G0802051, MC_UU_12012/5/B, MC_UU_12012/2] Funding Source: researchfish
- BBSRC [BB/H002731/1, BB/J009865/1] Funding Source: UKRI
- MRC [MC_UU_12012/2, G0802051] Funding Source: UKRI
Our understanding of adipose tissue biology has progressed rapidly since the turn of the century. White adipose tissue has emerged as a key determinant of healthy metabolism and metabolic dysfunction. This realization is paralleled only by the confirmation that adult humans have heat-dissipating brown adipose tissue, an important contributor to energy balance and a possible therapeutic target for the treatment of metabolic disease. We propose that the development of successful strategies to target brown and white adipose tissues will depend on investigations that elucidate their developmental origins and cell-type-specific functional regulators.
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