期刊
NATURE
卷 507, 期 7493, 页码 455-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nature12787
关键词
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资金
- MEXT
- MEXT, Japan
- European Research Council/ERC [204135]
- Novo Nordisk foundation
- Lundbeck foundation
- Deutsche Forschungsgemeinschaft [RE1310/7, RE1310/11, RE1310/13]
- Rudolf Bartling Stiftung
- BOLD MarieCurie ITN
- ZF-Health Integrated project of the European Commission
- Grants-in-Aid for Scientific Research [22228005, 24659373] Funding Source: KAKEN
- Biotechnology and Biological Sciences Research Council [BB/I024801/1, BBS/E/D/20251969] Funding Source: researchfish
- Lundbeck Foundation [R167-2013-15058] Funding Source: researchfish
- Medical Research Council [MC_UP_1102/1] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC0001211] Funding Source: researchfish
- BBSRC [BBS/E/D/20251969, BB/I024801/1] Funding Source: UKRI
- MRC [MC_UP_1102/1] Funding Source: UKRI
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers. We show that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity. The atlas is used to compare regulatory programs between different cells at unprecedented depth, to identify disease-associated regulatory single nucleotide polymorphisms, and to classify cell-type-specific and ubiquitous enhancers. We further explore the utility of enhancer redundancy, which explains gene expression strength rather than expression patterns. The online FANTOM5 enhancer atlas represents a unique resource for studies on cell-type-specific enhancers and gene regulation.
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