相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein-Coupled Receptors
Celine Valant et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)
Conserved activation pathways in G-protein-coupled receptors
Xavier Deupi et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Lifting the lid on GPCRs: the role of extracellular loops
M. Wheatley et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Agonist-bound structures of G protein-coupled receptors
Guillaume Lebon et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2012)
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
Demet Arac et al.
EMBO JOURNAL (2012)
Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design
Miles Congreve et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure of the δ-opioid receptor bound to naltrindole
Sebastien Granier et al.
NATURE (2012)
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Kazuko Haga et al.
NATURE (2012)
Structure of the human κ-opioid receptor in complex with JDTic
Huixian Wu et al.
NATURE (2012)
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
Aaron A. Thompson et al.
NATURE (2012)
Structure of the agonist-bound neurotensin receptor
Jim F. White et al.
NATURE (2012)
Structure and dynamics of the M3 muscarinic acetylcholine receptor
Andrew C. Kruse et al.
NATURE (2012)
High-resolution crystal structure of human protease-activated receptor 1
Cheng Zhang et al.
NATURE (2012)
Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II
Xavier Deupi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations
Karola M. Schlinkmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy
Rita Rahmeh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Crystal Structure of a Lipid G Protein-Coupled Receptor
Michael A. Hanson et al.
SCIENCE (2012)
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
Wei Liu et al.
SCIENCE (2012)
Versatility from Protein Disorder
M. Madan Babu et al.
SCIENCE (2012)
Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR
Jeffrey J. Liu et al.
SCIENCE (2012)
Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Tony Warne et al.
STRUCTURE (2012)
Domain coupling in GPCRs: the engine for induced conformational changes
Hamiyet Unal et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Diversity and modularity of G protein-coupled receptor structures
Vsevolod Katritch et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Structural insights into agonist-induced activation of G-protein-coupled receptors
Xavier Deupi et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)
Progress in Structure Based Drug Design for G Protein-Coupled Receptors
Miles Congreve et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Conformational Dynamics of Single G Protein-Coupled Receptors in Solution
Samuel Bockenhauer et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation
Kamonchanok Sansuk et al.
MOLECULAR PHARMACOLOGY (2011)
Structural and functional protein network analyses predict novel signaling functions for rhodopsin
Christina Kiel et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
Ka Young Chung et al.
NATURE (2011)
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
Guillaume Lebon et al.
NATURE (2011)
Structure of the human histamine H1 receptor complex with doxepin
Tatsuro Shimamura et al.
NATURE (2011)
Crystal structure of metarhodopsin II
Hui-Woog Choe et al.
NATURE (2011)
The structural basis of agonist-induced activation in constitutively active rhodopsin
Jorg Standfuss et al.
NATURE (2011)
The structural basis for agonist and partial agonist action on a β1-adrenergic receptor
Tony Warne et al.
NATURE (2011)
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Soren G. F. Rasmussen et al.
NATURE (2011)
Structure and function of an irreversible agonist-β2 adrenoceptor complex
Daniel M. Rosenbaum et al.
NATURE (2011)
Crystal structure of the β2 adrenergic receptor-Gs protein complex
Soren G. F. Rasmussen et al.
NATURE (2011)
Multiple ligand-specific conformations of the β2-adrenergic receptor
Alem W. Kahsai et al.
NATURE CHEMICAL BIOLOGY (2011)
Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers
Kou Qin et al.
NATURE CHEMICAL BIOLOGY (2011)
Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors
Angel Gonzalez et al.
PLOS ONE (2011)
Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives
Stephan Urwyler
PHARMACOLOGICAL REVIEWS (2011)
Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor
Rouslan Moukhametzianov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Activation mechanism of the β2-adrenergic receptor
Ron O. Dror et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Pathway and mechanism of drug binding to G-protein-coupled receptors
Ron O. Dror et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Structure of an Agonist-Bound Human A2A Adenosine Receptor
Fei Xu et al.
SCIENCE (2011)
A Polymorphism-Specific Memory Mechanism in the β2-Adrenergic Receptor
Andrea Ahles et al.
SCIENCE SIGNALING (2011)
Distinct Phosphorylation Sites on the β2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
Kelly N. Nobles et al.
SCIENCE SIGNALING (2011)
Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine
Andrew S. Dore et al.
STRUCTURE (2011)
Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX
Graham M. West et al.
STRUCTURE (2011)
Escaping the flatlands: new approaches for studying the dynamic assembly and activation of GPCR signaling complexes
Thomas Huber et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2011)
Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques
Davide Provasi et al.
PLOS COMPUTATIONAL BIOLOGY (2011)
The role of conformational ensembles of seven transmembrane receptors in functional selectivity
Nagarajan Vaidehi et al.
CURRENT OPINION IN PHARMACOLOGY (2010)
A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor
Dow P. Hurst et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes
Shixin Ye et al.
NATURE (2010)
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Michael P. Bokoch et al.
NATURE (2010)
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
Pil Seok Chae et al.
NATURE METHODS (2010)
Teaching old receptors new tricks: biasing seven-transmembrane receptors
Sudarshan Rajagopal et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
Beili Wu et al.
SCIENCE (2010)
Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
Ellen Y. T. Chien et al.
SCIENCE (2010)
The minor binding pocket: a major player in 7TM receptor activation
Mette M. Rosenkilde et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases
Martin Caffrey
ANNUAL REVIEW OF BIOPHYSICS (2009)
Engineering G protein-coupled receptors to facilitate their structure determination
Christopher G. Tate et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
Location of the Retinal Chromophore in the Activated State of Rhodopsin
Shivani Ahuja et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The structure and function of G-protein-coupled receptors
Daniel M. Rosenbaum et al.
NATURE (2009)
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
Yang Han et al.
NATURE CHEMICAL BIOLOGY (2009)
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Christian Heinis et al.
NATURE CHEMICAL BIOLOGY (2009)
Prediction of membrane protein structures with complex topologies using limited constraints
P. Barth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The rules of disorder or why disorder rules
Joerg Gsponer et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2009)
A G protein-coupled receptor at work: the rhodopsin model
Klaus Peter Hofmann et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Passing the baton in class B GPCRs: peptide hormone activation via helix induction?
Christoph Parthier et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Protein crystallography with a micrometre-sized synchrotron-radiation beam
Rouslan Moukhametzianov et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2008)
Structure of a β1-adrenergic G-protein-coupled receptor
Tony Warne et al.
NATURE (2008)
Crystal structure of opsin in its G-protein-interacting conformation
Patrick Scheerer et al.
NATURE (2008)
Crystal structure of squid rhodopsin
Midori Murakami et al.
NATURE (2008)
Crystal structure of the ligand-free G-protein-coupled receptor opsin
Jung Hee Park et al.
NATURE (2008)
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerstrom et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
Christian Altenbach et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
Veli-Pekka Jaakola et al.
SCIENCE (2008)
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
Vadim Cherezov et al.
SCIENCE (2007)
GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function
Daniel M. Rosenbaum et al.
SCIENCE (2007)
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
Soren G. F. Rasmussen et al.
NATURE (2007)
Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors
Terry Kenakin
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
Matthew R. Whorton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
G protein-coupled receptors show unusual patterns of intrinsic unfolding
VP Jaakola et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2005)
Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions
S Madabushi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structure of bovine rhodopsin in a trigonal crystal form
J Li et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
GM Suel et al.
NATURE STRUCTURAL BIOLOGY (2003)
Functionally different agonists induce distinct conformations in the G protein coupling domain of the β2 adrenergic receptor
P Ghanouni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystal structure of rhodopsin: A G protein-coupled receptor
K Palczewski et al.
SCIENCE (2000)
分享论文
