期刊
NATURE
卷 492, 期 7427, 页码 118-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11604
关键词
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资金
- German Research Foundation (DFG) [KL 2389/1-1, DO 1450/1-1, BI 1422/1-1]
- German National Academic Foundation
- Bill and Melinda Gates Foundation's Comprehensive Antibody Vaccine Immune Monitoring Consortium [1032144]
- American Liver Foundation
- CAVD from the Bill and Melinda Gates Foundation [OPP1033115]
- NIAID [1UM1AI100663]
- NIH [AI081677]
Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection(1,2). Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time(3,4). However, these experiments were performed before the recent discovery of more potent anti-HIV-1 antibodies and their improvement by structure-based design(5-9). Here we re-examine passive antibody transfer as a therapeutic modality in HIV-1-infected humanized mice. Although HIV-1 can escape from antibody monotherapy, combinations of broadly neutralizing antibodies can effectively control HIV-1 infection and suppress viral load to levels below detection. Moreover, in contrast to antiretroviral therapy(10-12), the longer half-life of antibodies led to control of viraemia for an average of 60 days after cessation of therapy. Thus, combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV-1-infected individuals.
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