期刊
NATURE
卷 491, 期 7424, 页码 393-398出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11622
关键词
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资金
- USDA CSREES/NIFA Swine Genome Coordination Program
- College of Agricultural, Consumer and Environmental Sciences, University of Illinois
- College of Agriculture and Life Sciences, Iowa State University
- North Carolina Agricultural Research Service
- USA National Pork Board
- Iowa Pork Producers Association
- North Carolina Pork Council
- Danish government
- TOPIGS Research Center IPG The Netherlands
- INRA Genescope, France
- Wellcome Trust Sanger Institute and BGI.
- BBSRC [BB/E010520/1, BB/E010520/2, BB/I025328/1, BB/H005935/1, BB/G004013/1]
- EC FP6 'Cutting edge genomics for sustainable animal breeding (SABRE)'
- EC FP7 'Quantomics'
- Australian NHMRC [575585]
- Next-Generation BioGreen 21 Program [PJ009019, PJ0081162012, PJ0080892011]
- RDA, Republic of Korea
- Ministry of Research (Spain)
- NIH [R13 RR020283A, NIH R13 RR032267A, ILLU 535-314, ILLU 538-379, ILLU-538-312, ILLU-538-34, 5 P41LM006252, P20-RR017686, 5 P41 LM006252]
- CSREES
- NIFA
- MAFF [IRPPIAUGT-AG 1101/1201]
- USDA-NRSP8 Bioinformatics Coordination and Pig Genome Coordination funds
- US-UK Fulbright Commission
- USDA-ARS Project Plan [1235-51000-055-00D, 1265-32000-098-00D]
- USDA AFRI NIFA/DHS [2010-39559-21860]
- USDA ARS
- USDA-NRSP8 Bioinformatics
- NSFC [31025026]
- Swedish Research Council FORMAS
- Swedish Wenner-Gren Foundations
- European Commission [LSHB-CT-2006-037377]
- BioGreen21
- RDA [PJ00622901, PJ00622902, PJ00622903, 20040301034467]
- European Research Council under the European Community [249894]
- NIH NIDA [P30 DA018310, R21 DA027548]
- ANR [ANR07-GANI-001]
- FTP/DFF [09-066598]
- DSF/Strategic Growth Technologies [09-067036]
- Lundbeck foundation [374/06]
- DCSC (Scientific Computing)
- Funds for International Cooperation from the Ministry of Science and Technology of China [2002AA229061]
- PL-Grid project: [POIG.02.03.00-00-007/08-00]
- USDA-NIFA-CREES [AG 2006-35216-16668, AG 2002-34480-11828, AG 2003-34480-13172, AG 2004-34480-14417, AG 2005-34480-15939, AG 2006-34480-17150, AG 2008-34480-19328, AG 2009-34480-19875, AG 2002-35205-12712, AG 2008-35205-18769, AG 2009-65205-05642, AG 2004-3881-02193]
- [USDA-NRI-2009-35205-05192]
- [USDA-NRI-2006-35204-17337]
- ICREA Funding Source: Custom
- BBSRC [BBS/E/D/20211550, BB/H005935/1, BB/G004013/1, BB/I025328/1, BB/E011640/1, BB/I025360/1, BBS/E/D/05191130, BB/E010768/1, BB/E010520/2, BBS/E/T/000PR5885, BB/E010520/1, BB/I025506/1] Funding Source: UKRI
- MRC [G0900950] Funding Source: UKRI
- NERC [NE/F003382/2, NE/H005269/1, NE/H005552/1, NE/F003382/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G004013/1, BB/E010520/2, BBS/E/D/05191130, BB/I025506/1, BB/I025328/1, BB/I025360/1, BBS/E/D/20211550, BB/E010520/1, BB/H005935/1, BB/E011640/1, BB/E010768/1] Funding Source: researchfish
- Chief Scientist Office [ETM/32] Funding Source: researchfish
- Medical Research Council [G0900950, G0900950B] Funding Source: researchfish
- Natural Environment Research Council [NE/F003382/2, NE/F003382/1, NE/H005269/1, NE/H005552/1] Funding Source: researchfish
For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars similar to 1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
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