期刊
NATURE
卷 482, 期 7385, 页码 331-338出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature10886
关键词
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资金
- National Science Foundation
- National Defense Science & Engineering Graduate Research Fellowship programs
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [950971] Funding Source: National Science Foundation
Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small RNAs are used to find and destroy foreign nucleic acids will provide new insights into the diverse mechanisms of RNA-controlled genetic silencing systems.
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