相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Quantifying the chemical beauty of drugs
G. Richard Bickerton et al.
NATURE CHEMISTRY (2012)
Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules
Tim Luker et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Getting pharmaceutical R&D back on target
Mark E. Bunnage
NATURE CHEMICAL BIOLOGY (2011)
The influence of the 'organizational factor' on compound quality in drug discovery
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Molecular obesity, potency and other addictions in drug discovery
Michael M. Hann
MEDCHEMCOMM (2011)
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
Travis T. Wager et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Physiochemical drug properties associated with in vivo toxicological outcomes
Jason D. Hughes et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The influence of drug-like concepts on decision-making in medicinal chemistry
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Assessment of the consistency of medicinal chemists in reviewing sets of compounds
MS Lajiness et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
A comparison of physiochemical property profiles of development and marketed oral drugs
MC Wenlock et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)