期刊
NATURE
卷 464, 期 7287, 页码 367-373出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08850
关键词
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资金
- USDA's National Institute of Food and Agriculture [2005-35600-16405]
- BBSRC [BBS/E/C/00004973] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00004973] Funding Source: researchfish
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [832760] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [846218] Funding Source: National Science Foundation
Fusarium species are among the most important phytopathogenic and toxigenic fungi. To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.
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