期刊
NATURE
卷 467, 期 7317, 页码 839-U103出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature09429
关键词
-
资金
- Carnegie Institution of Washington, NIH [K01AG031296]
- MWRI
- NSERC
Meiotic crossover (CO) recombination establishes physical linkages between homologous chromosomes that are required for their proper segregation into developing gametes, and promotes genetic diversity by shuffling genetic material between parental chromosomes. COs require the formation of double strand breaks (DSBs) to create the substrate for strand exchange. DSBs occur in small intervals called hotspots(1-3) and significant variation in hotspot usage exists between and among individuals(4). This variation is thought to reflect differences in sequence identity and chromatin structure, DNA topology and/or chromosome domain organization(1,5-9). Chromosomes show different frequencies of nondisjunction (NDJ)(10), reflecting inherent differences in meiotic crossover control, yet the underlying basis of these differences remains elusive. Here we show that a novel chromatin factor, X non-disjunction factor 1 (xnd-1), is responsible for the global distribution of COs in C. elegans. xnd-1 is also required for formation of double-strand breaks (DSBs) on the X, but surprisingly XND-1 protein is autosomally enriched. We show that xnd-1 functions independently of genes required for X chromosome-specific gene silencing, revealing a novel pathway that distinguishes the X from autosomes in the germ line, and further show that xnd-1 exerts its effects on COs, at least in part, by modulating levels of H2A lysine 5 acetylation.
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