期刊
NATURE
卷 469, 期 7330, 页码 407-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature09711
关键词
-
资金
- Friedrich Miescher Institute for Biomedical Research
- US Office of Naval Research
- Marie Curie Excellence grant
- National Centre of Competence in Research
- European Research Council
- European Union
- EMBO
Spatial asymmetries in neural connectivity have an important role in creating basic building blocks of neuronal processing(1,2). A key circuit module of directionally selective (DS) retinal ganglion cells is a spatially asymmetric inhibitory input from starburst amacrine cells(3-5). It is not known how and when this circuit asymmetry is established during development. Here we photostimulate mouse starburst cells targeted with channelrhodopsin-2 (refs 6-8) while recording from a single genetically labelled type of DS cell(9,10). We follow the spatial distribution of synaptic strengths between starburst and DS cells during early postnatal development before these neurons can respond to a physiological light stimulus, and confirm connectivity by monosynaptically restricted trans-synaptic rabies viral tracing. We show that asymmetry develops rapidly over a 2-day period through an intermediate state in which random or symmetric synaptic connections have been established. The development of asymmetry involves the spatially selective reorganization of inhibitory synaptic inputs. Intriguingly, the spatial distribution of excitatory synaptic inputs from starburst cells is significantly more symmetric than that of the inhibitory inputs at the end of this developmental period. Our work demonstrates a rapid developmental switch from a symmetric to asymmetric input distribution for inhibition in the neural circuit of a principal cell.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据