期刊
NATURE
卷 460, 期 7257, 页码 839-847出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08302
关键词
-
资金
- Deutsche Forschungsgemeinschaft
- Bundeministerium fur Bildung und Forschung
- Fonds der Chemischen Industrie
- European Union
- US National Institutes of Health [GM-67626]
The trace element molybdenum is essential for nearly all organisms and forms the catalytic centre of a large variety of enzymes such as nitrogenase, nitrate reductases, sulphite oxidase and xanthine oxidoreductases. Nature has developed two scaffolds holding molybdenum in place, the iron-molybdenum cofactor and pterin-based molybdenum cofactors. Despite the different structures and functions of molybdenum-dependent enzymes, there are important similarities, which we highlight here. The biosynthetic pathways leading to both types of cofactor have common mechanistic aspects relating to scaffold formation, metal activation and cofactor insertion into apoenzymes, and have served as an evolutionary 'toolbox' to mediate additional cellular functions in eukaryotic metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据