期刊
NATURE
卷 460, 期 7257, 页码 848-854出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08303
关键词
-
资金
- US National Science Foundation Division of Chemistry [0719553]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0719553] Funding Source: National Science Foundation
In nature, halogenation is a strategy used to increase the biological activity of secondary metabolites, compounds that are often effective as drugs. However, halides are not particularly reactive unless they are activated, typically by oxidation. The pace of discovery of new enzymes for halogenation is increasing, revealing new metalloenzymes, flavoenzymes, S-adenosyl-l-methionine (SAM)-dependent enzymes and others that catalyse halide oxidation using dioxygen, hydrogen peroxide and hydroperoxides, or that promote nucleophilic halide addition reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据