期刊
NATURE
卷 459, 期 7245, 页码 356-363出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature08144
关键词
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资金
- US National Institute of General Medical Sciences [F32 GM082028, RO1GM083118]
- Lundbeck Foundation
- National Institute of Neurological Disorders and Stroke [RO1-NS28471]
- Mather Charitable Foundation
- Lundbeck Foundation [R19-2008-2113] Funding Source: researchfish
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.
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