期刊
NATURE
卷 458, 期 7242, 页码 1127-1130出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07986
关键词
-
资金
- NIH
- American Lebanese and Syrian Associated Charities
- Ligue contre le Cancer
- INCa
- Canceropole
- ANR
- ANRS
- Active p53
- Apo-Sys EU networks
The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据