期刊
NATURE
卷 458, 期 7238, 页码 636-640出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07930
关键词
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资金
- Rockefeller University
- International Aids Vaccine Initiative
- Bill and Melinda Gates Foundation
- Intramural Research Program of the Vaccine Research Center
- Division of Intramural Research
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Deutscher Akademischer Austauschdienst
- Fondation Recherche Medicale
Antibodies to conserved epitopes on the human immunodeficiency virus (HIV) surface protein gp140 can protect against infection in non-human primates, and some infected individuals show high titres of broadly neutralizing immunoglobulin (Ig)G antibodies in their serum. However, little is known about the specificity and activity of these antibodies(1-3). To characterize the memory antibody responses to HIV, we cloned 502 antibodies from HIV envelope-binding memory B cells from six HIV-infected patients with broadly neutralizing antibodies and low to intermediate viral loads. We show that in these patients, the B-cell memory response to gp140 is composed of up to 50 independent clones expressing high affinity neutralizing antibodies to the gp120 variable loops, the CD4-binding site, the co-receptor-binding site, and to a new neutralizing epitope that is in the same region of gp120 as the CD4-binding site. Thus, the IgG memory B-cell compartment in the selected group of patients with broad serum neutralizing activity to HIV is comprised of multiple clonal responses with neutralizing activity directed against several epitopes on gp120.
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