期刊
NATURE
卷 452, 期 7188, 页码 759-U8出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature06859
关键词
-
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL078891, R01 HL078891-02, R01 HL078891-03, R01 HL078891-01A1] Funding Source: Medline
- NINDS NIH HHS [R37 NS034814, R37 NS034814-12, R37 NS034814-11, R37 NS034814-11S1, R37 NS034814-13] Funding Source: Medline
During development, sympathetic neurons extend axons along a myriad of distinct trajectories, often consisting of arteries, to innervate one of a large variety of distinct final target tissues. Whether or not subsets of neurons within complex sympathetic ganglia are predetermined to innervate select end-organs is unknown. Here we demonstrate in mouse embryos that the endothelin family member Edn3 (ref. 1), acting through the endothelin receptor EdnrA (refs 2, 3), directs extension of axons of a subset of sympathetic neurons from the superior cervical ganglion to a preferred intermediate target, the external carotid artery, which serves as the gateway to select targets, including the salivary glands. These findings establish a previously unknown mechanism of axonal pathfinding involving vascular-derived endothelins, and have broad implications for endothelins as general mediators of axonal growth and guidance in the developing nervous system. Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据