期刊
NATURE
卷 455, 期 7209, 页码 114-U82出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07198
关键词
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资金
- Australian CJ Martin Fellowship [310616]
- Medical Research Council career development fellowship
- European Molecular Biology Organization
- Medical Research Council career development fellowships
- European Commission 6th Framework Programme for Research and Technological Development
- Medical Research Council
- MRC [MC_U117570528] Funding Source: UKRI
- Medical Research Council [MC_U117570528] Funding Source: researchfish
Motility is a universal property of newly generated neurons. How cell migration is coordinately regulated with other aspects of neuron production is not well understood. Here we show that the proneural protein neurogenin 2 ( Neurog2), which controls neurogenesis in the embryonic cerebral cortex(1,2), directly induces the expression of the small GTP- binding protein Rnd2 ( ref. 3) in newly generated mouse cortical neurons before they initiate migration. Rnd2 silencing leads to a defect in radial migration of cortical neurons similar to that observed when the Neurog2 gene is deleted. Remarkably, restoring Rnd2 expression in Neurog2- mutant neurons is sufficient to rescue their ability to migrate. Our results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration. Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP- binding protein.
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