期刊
NATURE
卷 453, 期 7198, 页码 1051-1057出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07036
关键词
-
资金
- NIAID NIH HHS [R01 AI073542-02, R01 AI073542-01, R01 AI073542] Funding Source: Medline
- NINDS NIH HHS [R01 NS059996] Funding Source: Medline
T helper (T-H) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their unique cytokines and effector functions mediate different types of tissue inflammation. The recently discovered T(H)17 cells, the third subset of effector T helper cells, have been the subject of intense research aimed at understanding their role in immunity and disease. Here we review emerging data suggesting that T(H)17 cells have an important role in host defence against specific pathogens and are potent inducers of autoimmunity and tissue inflammation. In addition, the differentiation factors responsible for their generation have revealed an interesting reciprocal relationship with regulatory T (T-reg) cells, which prevent tissue inflammation and mediate self-tolerance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据