期刊
NATURE
卷 453, 期 7193, 页码 406-U61出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature06849
关键词
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资金
- NEI NIH HHS [R01 EY007492-19, R01 EY007492] Funding Source: Medline
We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex(1-11) that are anatomically connected into long-range circuits(12). These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.
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