期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 15, 页码 2215-2222出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1496430
关键词
Lasiodiplodia theobromae; fungi; mangrove sediment; depsidones; botryorhodines; biological activity
资金
- DFG [GRK 2158]
- Manchot Foundation
A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 mu M whereas compound 7 showed selective anti-bacterial activity against different S. aureus and E. faecium bacterial strains with MIC value of 25 mu g/ml. [GRAPHICS] .
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